CpG ODN Vaccine Adjuvant Synthesis Services
CpG ODN is a vaccine adjuvant that can increase the response speed of the vaccine, enhance the response intensity and immune tolerance of the vaccine, and is safe and effective for humans. By artificially synthesizing unmethylated CpG oligodeoxynucleotide chains, it can interact with Toll-like receptors on the endoplasmic reticulum membrane in immune cells such as B cells, dendritic cells, monocytes, and macrophages. The combination of TLR9) can improve the immunogenicity of the vaccine and has better safety. It has broad application prospects for the prevention and treatment of infections, tumors, allergies and other diseases, and can enhance the specific response to vaccines.
CpG ODN vaccine adjuvant synthesizer
Creative Biolabs is a professional biotechnology services platform; provide outsourced experiments for oligonucleotide synthesis research. We have professional researchers and strict quality control to ensure the synthesis of CpG ODN vaccine adjuvant.
Mechanism of action of CpG ODN vaccine adjuvant
Structural characteristics and application directions of 3 types of CpG ODN:
| Type | Type A (Type D) | Type B (Type K) | Type C |
| Structure | Partly thiomodification, it shows an ordered c-tetramer structure | All thiogenic modifications, including I or more CpC motils | The 3" terminal palindromic sequence formed a dimer with all thiotropic modifications |
| Function | Stimulation of Plasnayoid dendritieells (PDC) produces a large amount of Type I interferon (IFNa). And can strongly activate NK cells | It strongly stimulates B cell proliferation and secretes large amounts of immunoglobulin. Interleukin-6. Ll-10 and IL-12, and can stimulate PDC maturation. Activated NK cells are less effective than type A cells | It also has the function characteristics of type A and type B CpC 0DN |
| Application direction | Antitumor. Antiviral adjuvant is used to treat immunodeficiency | Subunit vaccine, DNA vaccine and other vaccine adjuvants | It combines all application directions of both type A and type B |
Features of CpG ODN vaccine adjuvant:
- As a vaccine adjuvant, it has high safety at low doses and improves the response rate of the vaccinated population, and it has unique advantages as a neonatal vaccine adjuvant.
- Combined use with anti-tumor vaccines such as thymoma can effectively activate the body's multiple specific immune responses and enhance the vaccine effect.
- CpG ODN is used as an adjuvant alone, synergistically immunized with traditional adjuvants such as aluminum adjuvant, or combined with a variety of new adjuvants to improve the immune efficacy.
- By changing the pharmacy-related parameters of CpG ODN, it can improve the therapeutic effect of diseases to a certain extent.
- CpG ODN can be synthesized artificially and can be applied to a variety of antigens. It is stored as a freeze-dried powder and is stable and easy to transport.
References
- Bode C, Zhao G, Steinhagen F, et al. CpG DNA as a vaccine adjuvant. Expert Rev Vaccines, 2011, 10(4):499-511.
- Bodera P, Stankiewicz W, et al. Synthetic immunostimulatory ol-igonucleotides in experimental and clinical practice. Pharmaeol Rep,2012,64(5): 1003-1010.
*For Research Use Only. Not for use in diagnostic procedures.
