Large-Scale Oligo Synthesis Service
In the past few decades, synthetic oligonucleotides have been proven to be useful for therapeutic applications. Among them, 7 oligonucleotide drugs have been successfully approved by the FDA, and many oligonucleotides are undergoing clinical trials all over the world. The demand for a large number of oligonucleotide materials with potential therapeutic value has increased dramatically, leading to more cost-effective manufacturing techniques. The use of high-purity raw materials improves the quality of synthetic oligonucleotides, while at the same time, the yield and throughput have been significantly increased. And through continuous development and optimization of the oligonucleotide manufacturing process, oligonucleotide manufacturers are allowed to obtain a variety of oligonucleotide modifications[1].
With increasing numbers of nondeductible products in the clinic and the successful outcome of these trials, large-scale production of mononucleosis at low cost would be mandatory. The nondeductible manufacturing process consists of five major steps, (1) synthesis, (2) cleavage and deprecation (C&D), (3) purification, (4) desalting and concentration and (5) materialization, as shown in Fig1.
Fig1. nondeductible manufacturing process steps[1]
Developing low-cost approaches for nondeductible synthesis is of importance and has gained widespread interest. Automated synthesis on solid supports using organophosphate chemistry has been the most successful method for large-scale synthesis of nondeductible phosphorothioate-based drugs.
Creative Biolabs is the world's leading supplier of DNA or RNA products and services. We have a leading nucleic acid synthesis, purification and analysis platform and professional talents to provide high-quality and reliable cGMP-level and non-cGMP-level oligonucleotide products. Our professional team is experienced in large-scale DNA/RNA synthesis and various chemical modifications, providing strong support throughout the production process for global partners.
Our Large-Scale DNA or RNA Oligonucleotide Synthesis Services
Our oligonucleotide products are purified by HPLC/ PAGE and verified by independent QA (Quality Assurance) procedures to be having extremely low mutation and low error rates. We guarantee that our DNA or RNA oligonucleotides are of the highest quality. The products can be widely used in precision medicine, genetic disease testing, infectious disease testing, food, agriculture and other industries.
Modifications and Probes |
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Backbone Modifications |
Linker Modifications | qPCR Probes | |
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Advantages of Our Services:
- Modifications available
- Fast and cost-effective
- Ships within 10 business days
- Quality ensured by 100% QC
Deliverables:
- Custom formulation and packaging
- mg to 50 gram/batch
- Unmodified DNA lengths between 4–100 bases
- Unmodified RNA lengths between 4–70 bases
- Lyophilized oligo powder
- COA file
QC Analysis:
- HPLC/LC-MS
- Endotoxin Control/Bioburden (optional)
Reference
- Satoshi Obika·Mitsuo Sekine. Large-Scale Oligonucleotide Manufacturing. Synthesis of Therapeutic Oligonucleotides. 97-98(2018)
*For Research Use Only. Not for use in diagnostic procedures.
