Nucleic Acid Drug CRO
Creative Biolabs provides solutions for the whole process of R&D of nucleic acid drug, including drug target screening, oligonucleotide drug design and synthesis, leading molecule discovery, leading molecule optimization, drug candidate screening and validation, drug toxicity evaluation, optimization verification and animal testing. Our nucleic acid drug CRO technical service platform includes nucleotide synthesis, high content cell screening, cell chemiluminescence analysis, cell viability, proliferation, apoptosis and toxicity analysis, human genome siRNA library, micrornas library, nucleic acid and protein analysis platform, chromatography - mass spectrometry analysis platform, high-throughput sequencing platform and animal experiment platform. The advanced in vitro and in vivo analytical methods can help customers to accelerate the process of nucleic acid drug discovery.
Services We Can Provide：
1. Target Screening, Identification and Validation
Target screening, identification and validation of new drug targets not only provide important information for revealing the mechanism of drug action, but also have important significance for the development of new drugs, the establishment of screening models, and the discovery of lead compounds.
We provide but are not limited to:
- High-Throughput Screening/High-Content Screening
- Computer-Aided Target Identification and Validation
- Gene manipulation
- Structure Determination
- Functional Analysis
2. Oligonucleotide Drug Design
Oligonucleotides (ONs) are a class of drugs that are composed of 12 to 30 single or double chains of ribose oligonucleotides synthesized by artificial chemistry. They act on target messenger RNA(mRNA) by Watson-Crick base pairing principle. They can be divided into two major categories, including antisense oligonucleotides (ASODN) and small interference RNA (siRNA). Creative Biolabs provides high quality customized oligonucleotide drug design services.
Services We Can Provide:
- Design, Optimization and Coupling Process Development of ASODN.
- Design, Chemical Modification and Coupling Process Development of siRNA.
- Design and Chemical Modification of CpG Oligonucleotide.
- Design and Chemical Modification of miRNA and Anti-miRNA Oligo.
- Design of Triplex Forming Oligonucleotide.
- Design and Chemical Modification of Decoy.
3. Oligonucleotide Synthesis Service
Creative Biolabs has advanced RNA nucleotide synthesis technology, providing a wide range of oligonucleotide nucleic acid (RNA) and its derivatives synthesis services, including the synthesis of natural siRNA, miRNA and other small RNA or non-natural and more stable oligonucleotide nucleic acids (GMP and non-cGMP). The significant advantages of Creative Biolabs's oligonucleotide synthesis service lie in its fast cycle, superior method, good quality and variety of products. Creative Biolabs has been providing high-quality nucleic acid synthesis and formulation services to global partners for many years.
Services We Can Provide:
- siRNA Synthesis Services.
- CRISPR crRNA, tracrRNA, gRNA Synthesis Services.
- miRNAs Synthesis Services.
- Antisense Nucleic Acid Synthesis Services.
- Aptamer Screening Services.
- CpG ODN Vaccine Adjuvant Synthesis Services.
- Locked Nucleic Acid Synthesis Services.
- Taqman Probe Synthesis Services.
- DNA Probe Synthesis Services.
- RNA Probe Synthesis Services.
4. The Discovery and Optimization of Nucleic Acid Drug Candidates
Creative Biolabs helps clients turn hits from screening into lead compounds that can be further optimized, realizing the discovery of nucleic acid drug candidates. The lead compound can be a screened hit or a series of homologues. For high-throughput screening, there are discrete and multi-series hits. This requires the selection of one of the series for further study, which is the process of Hit to Lead. Creative Biolabs has advanced computing tools, highly automated analytical instruments and efficient integration capabilities to help customers achieve this. The selection of a lead compound for preclinical evaluation can transform it into a nucleic acid drug candidate and optimize the lead compound.
Services We Can Provide:
- Chemical Modifications of Nucleic Acid Drug.
- Targeting Delivery Study Service.
- Evaluation of Specific Receptor Affinity.
- Study on Structure-Activity Relationship of Oligonucleotide Drugs.
- Study on In Vitro and In Vivo Stability of Oligonucleotide Drugs.
- In Vivo Activity Evaluation of Oligonucleotide Drugs.
- Exposure – Effects Analysis Service.
- In Vitro ADME Service.
Druggability refers to the ADME properties and safety properties, including appropriate physicochemical, biochemical, pharmacokinetic, safety and structural novelty, which are sufficient to enable the active compound to enter phase I clinical trials. Druggability is an essential characteristic of a candidate drug or even a drug and is the goal of lead optimization and drug candidates. Druggability is an important pillar of new drug development. The evaluation of the druggability of candidate drugs belongs to the development stage of drugs, which includes preclinical comprehensive evaluation, clinical evaluation and industrialization research. The comprehensive evaluation of pre-clinical druggability is the bottleneck of the low efficiency of new drug creation.
Services We Can Provide:
- Physico-Chemical Service.
- Biochemistry Study Service.
- Pharmacokinetic Study Service.
- Toxic Side Effects Service.
6. Early Toxicological Evaluation Service
Creative Biolabs provides a variety of efficient early toxicological evaluation services to support early drug development and selection/optimization. According to customer requirements, Creative Biolabs can conduct in vitro toxicology evaluation and in vivo toxicological evaluation to evaluate the toxicity tendency, so that customers can optimize the compounds with a high probability of success as soon as possible. Creative Biolabs has an internationally certified laboratory that can carry out a full range of early toxicological evaluation.
Services We Can Provide:
- In vitroToxicity Evaluation Services.
- In VivoToxicological Evaluation Services.
7. ADME and Pharmacokinetic Services
Services We Can Provide:
- In Vitro Metabolism.
- In Vitro Permeability and Transporters.
- Polymorphic and Non-CYP Mediated Metabolism.
- Protein Binding.
Services We Can Provide:
- Drug Stability Service.
- Hepatic Targeting Service.
- Tumor Targeting Service.
- Protein Binding.
9. Modeling and Research of Animal Disease Model
Services We Can Provide:
- Subcutaneous Tumor Modeling In Mouse.
- Fluorescence Imaging Detection Service.
- Bioluminescence Imaging Detection Service.
- Small Animal X-Ray Imaging Service.
10. Gene and Protein Expression Detection
Services We Can Provide:
- Gene Expression Detection.
- Protein Expression Detection.
11. Biomarker Analysis
Services We Can Provide:
- Real-Time Quantitative PCR Analysis.
- MicroRNA Expression Profiling Services.
- SNP Genotyping Service.
- Multiple Biomarker Analysis.
- Flow Cytometry Analysis.
Creative Biolabs is a professional biotechnology service platform that provides nucleic acid drug CRO technical service. Thank you for choosing our service. If you have any questions, please contact our staff, we will answer and serve you immediately.
*For Research Use Only. Not for use in diagnostic procedures.
